2023 in Evaluation
Health And Wellness Research Study + Technology: A Juncture
Palantir Factory has actually long been instrumental in increasing the research study searchings for of our health and life scientific research companions, assisting attain extraordinary insights, improve data gain access to, improve data usability, and facilitate sophisticated visualization and evaluation of data sources– all while securing the privacy and safety and security of the backing data
In 2023, Foundry supported over 50 peer-reviewed publications in prestigious journals, covering a diverse variety of topics– from healthcare facility operations, to oncological drugs, to learning modalities. The year prior, our software sustained a document number of peer-reviewed publications, which we highlighted in a prior article
Our partners’ fundamental financial investments in technical framework during the optimal of the COVID- 19 pandemic has made the outstanding quantity of magazines possible.
Public and industrial health care partners have actually proactively scaled their investments in data sharing and research study software past COVID feedback to construct a much more comprehensive information structure for biomedical research study. As an example, the N 3 C Enclave — which houses the data of 21 5 M individuals from across nearly 100 institutions– is being made use of everyday by hundreds of researchers throughout firms and companies. Given the intricacy of accessing, organizing, and harnessing ever-expanding biomedical data, the need for comparable study sources remains to increase.
In this post, we take a closer consider some significant magazines from 2023 and examine what exists in advance for software-backed study.
Emerging Technology and the Acceleration of Scientific Research
The effect of new technologies on the clinical business is speeding up research-based outputs at a previously impossible range. Arising technologies and advanced software are aiding create extra precise, arranged, and obtainable information properties, which subsequently are enabling researchers to tackle progressively complex scientific challenges. Specifically, as a modular, interoperable, and versatile system, Factory has been used to support a varied range of clinical research studies with unique research features, including AI-assisted therapeutics identification, real-world proof generation, and more.
In 2023, the market has actually also seen an exponential development in interest around utilizing Artificial Intelligence (AI)– and specifically, generative AI and huge language models (LLM)– in the health and life science domains. Along with other core technical advancements (e.g., around data high quality and usability), the capacity for AI-enabled software application to increase scientific study is much more appealing than ever. As a commercial leader in AI-enabled software application, Palantir has actually gone to the center of searching for responsible, secure, and reliable ways to use AI-enabled capacities to support our partners throughout industries in attaining their crucial goals.
Over the previous year, Palantir software application helped drive key parts of our partners’ research study and we stand prepared to continue working together with our partners in federal government, industry, and civil culture to tackle the most pressing challenges in wellness and science in advance. In the next area, we give concrete examples of exactly how the power of software application can help advance clinical research, highlighting some essential biomedical publications powered by Foundry in 2023
2023 Publications Powered by Palantir Foundry
Along with a number of important cancer and COVID therapy studies, Palantir Foundry likewise made it possible for brand-new searchings for in the broader area of research methodology. Below, we highlight a sample of some of the most impactful peer-reviewed short articles published in 2023 that used Palantir Shop to assist drive their study.
Identifying brand-new reliable drug mixes for multiple myeloma
- Magazine : Cancer cells Letters
- Writers : Peat, T.J., Gaikwad, S.M., Dubois, W., Gyabaah-Kessie, N., Zhang, S., Gorjifard, S., Phyo, Z., Andres, M., Hughitt, V.K., Simpson, R.M., Miller, M.A., Girvin, A.T., Taylor, A., Williams, D., D’Antonio, N., Zhang, Y., Rajagopalan, A., Flietner, E., Wilson, K., Zhang, X., Shinn, P., Klumpp-Thomas, C., McKnight, C., Itkin, Z., Chen, L., Kazandijian, D., Zhang, J., Michalowski, A.M., Simmons, J.K., Keats, J., Thomas, C.J., Mock, B.A.
- Summary : Several myeloma (MM) is regularly resistant to drug treatment, calling for ongoing expedition to recognize brand-new, efficient therapeutic combinations. In this research study, researchers utilized high-throughput medicine screening to recognize over 1900 substances with activity versus at the very least 25 of the 47 MM cell lines examined. From these 1900 substances, 3 61 million mixes were examined in silico, and sets of substances with highly associated activity across the 47 cell lines and various mechanisms of activity were selected for additional analysis. Especially, six (6 medication combinations worked at 1 lowering over-expression of a key healthy protein (MYC) that is typically linked to the production of deadly cells and 2 boosted expression of the p 16 protein, which can help the body subdue lump growth. Moreover, 3 (3 recognized medicine mixes enhanced possibilities of survival and reduced the development of cancer cells, partly by minimizing task of paths involved in TGFβ/ SMAD signaling, which regulate the cell life process. These preclinical findings determine potentially useful novel medicine combinations for challenging to treat numerous myeloma.
New rank-based healthy protein category approach to enhance glioblastoma therapy
- Magazine : Cancers
- Writers : Tasci, E., Jagasia, S., Zhuge, Y., Sproull, M., Cooley Zgela, T., Mackey, M., Camphausen, K., Krauze, A.V.
- Summary : Glioblastomas, the most common sort of malignant brain tumors, vary substantially, limiting the ability to evaluate the biological factors that drive whether glioblastomas will certainly reply to treatment. However, information analysis of the proteome– the entire set of proteins that can be expressed by the lump– can 1 deal non-invasive methods of classifying glioblastomas to assist inform treatment and 2 recognize protein biomarkers related to treatments to evaluate reaction to treatment. In this research, researchers created and checked an unique rank-based weighting technique (“RadWise”) for protein features to help ML algorithms concentrate on the the most appropriate aspects that indicate post-therapy results. RadWise supplies a more efficient pathway to determine the proteins and attributes that can be vital targets for treatment of these aggressive, deadly lumps.
Identifying liver cancer subtypes most likely to reply to immunotherapy
- Magazine : Cell Reports Medicine
- Authors : Budhu, A., Pehrsson, E.C., He, A., Goyal, L., Kelley, R.K., Dang, H., Xie, C., Monge, C., Tandon, M., Ma, L., Revsine, M., Kuhlman, L., Zhang, K., Baiev, I., Lamm, R., Patel, K., Kleiner, D.E., Hewitt, S.M., Tran, B., Shetty, J., Wu, X., Zhao, Y., Shen, T.W., Choudhari, S., Kriga, Y., Ylaya, K., Detector, A.C., Edmondson, E.F., Forgues, M., Greten, T.F., Wang, X.W.
- Summary : Liver cancer cells is an increasing reason for cancer cells fatalities in the United States. This study investigated variation in client outcomes for a type of immunotherapy using immune checkpoint preventions. Scientist noted that particular molecular subtypes of cancer, defined by 1 the aggression of cancer cells and 2 the microenvironment of the cancer cells, were linked to higher survival rates with immune checkpoint inhibitor therapy. Determining these molecular subtypes can aid physicians determine whether a patient’s distinct cancer cells is likely to reply to this sort of intervention, meaning they can use more targeted use of immunotherapy and boost chance of success.
Applying formulas to EHR information to infer maternity timing for more accurate mother’s health research
- Magazine : JAMIA, Female’s Health Scandal sheet
- Authors : Jones, S., Bradwell, K.R. *, Chan, L.E., McMurry, J.A., Olson-Chen, C., Tarleton, J., Wilkins, K.J., Qin, Q., Faherty, E.G., Lau, Y.K., Xie, C., Kao, Y.H., Liebman, M.N., Ljazouli, S. *, Mariona, F., Challa, A., Li, L., Ratcliffe, S.J., Haendel, M.A., Patel, R.C., Hillside, E.L.
- Recap : There are indications that COVID- 19 can trigger pregnancy difficulties, and expecting persons seem at higher danger for more severe COVID- 19 infection. Evaluation of health and wellness document (EHR) data can help supply more insight, however as a result of data inconsistencies, it is commonly hard to establish 1 maternity start and end days and 2 gestational age of the infant at birth. To assist, scientists adapted an existing formula for establishing gestational age and maternity size that relies upon analysis codes and delivery days. To enhance the precision of this formula, the researchers layered by themselves data-driven formulas to specifically presume maternity beginning, maternity end, and site time frames throughout a pregnancy’s development while additionally dealing with EHR data variance. This approach can be dependably made use of to make the foundational inference of pregnancy timing and can be applied to future pregnancy and maternity study on topics such as adverse pregnancy results and maternal mortality.
An unique method for solving EHR data top quality problems for professional experiences
- Magazine : JAMIA
- Authors : Leese, P., Anand, A., Girvin, A. *, Manna, A. *, Patel, S., Yoo, Y.J., Wong, R., Haendel, M., Chute, C.G., Bennett, T., Hajagos, J., Pfaff, E., Moffitt, R.
- Recap : Clinical experience data can be a rich source for study, yet it commonly differs considerably throughout suppliers, centers, and institutions, making it challenging to consistently examine. This variance is multiplied when multisite electronic health record (EHR) information is networked with each other in a central database. In this study, scientists created a novel, generalizable approach for resolving professional experience data for analysis by combining related encounters right into composite “macrovisits.” This method assists adjust and deal with EHR encounter data problems in a generalizable, repeatable means, enabling researchers to more easily open the potential of this abundant data for large studies.
Improving openness in phenotyping for Long COVID research study and beyond
- Publication : Journal of the American Medical Informatics Association
- Authors : Pfaff, E.R., Girvin, A.T. *, Crosskey, M., Gangireddy, S., Master, H., Wei, W.Q., Kerchberger, V.E., Weiner, M., Harris, P.A., Basford, M., Lunt, C., Chute, C.G., Moffitt, R.A., Haendel, M.; N 3 C and RECOVER Consortia
- Recap : Phenotyping, the procedure of assessing and categorizing an organism’s attributes, can assist scientists much better recognize the distinctions between people and groups of people, and to identify certain qualities that may be linked to specific diseases or conditions. Artificial intelligence (ML) can assist acquire phenotypes from information, yet these are challenging to share and replicate because of their complexity. Researchers in this research devised and educated an ML-based phenotype to determine individuals highly probable to have Long COVID, a significantly immediate public health factor to consider, and showed applicability of this technique for other settings. This is a success tale of just how clear innovation and partnership can make phenotyping formulas a lot more obtainable to a wide audience of scientists in informatics, lowering copied work and giving them with a tool to get to insights quicker, including for various other illness.
Browsing difficulties for multisite real world information (RWD) data sources
- Magazine : BMC Medical Research Technique
- Writers : Sidky, H., Young, J.C., Girvin, A.T. *, Lee, E., Shao, Y.R., Hotaling, N., Michael, S., Wilkins, K.J., Setoguchi, S., Funk, M.J.; N 3 C Consortium
- Recap : Working with huge scale systematized EHR data sources such as N 3 C for research study needs specialized understanding and cautious analysis of data high quality and completeness. This study checks out the process of assessing information quality in preparation for study, focusing on medicine efficacy studies. Scientist recognized a number of methods and finest practices to better characterize vital study components consisting of direct exposure to treatment, baseline wellness comorbidities, and crucial outcomes of passion. As huge scale, systematized real world databases come to be more prevalent, this is a handy advance in helping scientists more effectively browse their unique information difficulties while unlocking essential applications for medicine advancement.
What’s Following for Health And Wellness Research at Palantir
While 2023 saw crucial progression, the brand-new year brings with it brand-new possibilities, as well as an urgency to use the most recent technological improvements to one of the most vital wellness issues dealing with individuals, neighborhoods, and the general public at big. As an example, in 2023, the U.S. Government declared its dedication to combating systemic illness such as cancer cells, and even introduced a brand-new health and wellness agency, the Advanced Study Projects Firm for Health And Wellness ( ARPA-H
Moreover, in 2024, Palantir is happy to be a sector companion in the innovative National AI Research Resource (NAIRR) pilot program , created under the auspices of the National Scientific Research Structure (NSF) and with funding from the NIH. As part of the NAIRR pilot– whose launch was routed by the Biden Management’s Executive Order on Expert System — Palantir will certainly be dealing with its long-time partners at the National Institutes of Wellness (NIH) and N 3 C to support research ahead of time risk-free, protected, and trustworthy AI, as well as the application of AI to obstacles in medical care.
In 2024, we’re delighted to deal with partners, brand-new and old, on problems of critical significance, using our understandings on information, tools, and research study to aid enable purposeful improvements in wellness outcomes for all.
To find out more concerning our continuing job throughout health and life scientific researches, check out https://www.palantir.com/offerings/federal-health/
* Authors connected with Palantir Technologies